abstract：:We evaluated the prognostic significance of p34cdc2 expression in 50 tongue squamous cell carcinomas (SCC) using immunohistochemical methods. The p34cdc2 protein was expressed in 33 cases of 50 tumor tissues (66.0%), compared with 15 cases of 42 controlled epithelia (35.7%). The expression of p34cdc2 was significantly...

journal_title：Oral oncology

authors： Wada S,Yue L,Furuta I

更新日期：2004-02-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) A is known to play an important role in tumor angiogenesis. The additional members of the VEGF family, VEGF B, C and D have been discovered. VEGF C and D show some selectivity toward lymphatic endothelial cells. However, whether VEGF family members play a role in tumor angioge...

journal_title：Oral oncology

authors： Shintani S,Li C,Ishikawa T,Mihara M,Nakashiro K,Hamakawa H

更新日期：2004-01-01 00:00:00

abstract：:In this study conducted amongst Indian male tobacco users with upper aero-digestive tract (UADT) squamous carcinoma, 30 patients with multiple primary neoplasms (MPN) were compared with 28 age and sex matched patients with a single primary neoplasm (SPN) for various environmental factors (form of tobacco use, alcohol,...

journal_title：Oral oncology

authors： Jhavar S,Sarin R,Mulherkar R,Benner A,Agarwal JP,Dinshaw K

更新日期：2004-01-01 00:00:00

abstract：:This study was aimed at estimating the pooled global leukoplakia prevalence using both well-designed studies, which were too few to be representative of the world situation, and less valuable studies. The inverse variance weighting and the random effect methods were used. The latter is based on the principle that if p...

journal_title：Oral oncology

authors： Petti S

更新日期：2003-12-01 00:00:00

abstract：:The present study sought to determine the potential role of stress activated MAPK and phosphatidylinositol 3-kinase (PI3K) signaling pathways in mediating phenotypic switching between angiogenic and angiostatic elements among squamous cell carcinoma (SCC) cell lines. In particular, we investigated the effects of hypox...

journal_title：Oral oncology

authors： Stewart J,Siavash H,Hebert C,Norris K,Nikitakis NG,Sauk JJ

更新日期：2003-12-01 00:00:00

abstract：:The aim of this study was to evaluate the reliability and utility of a histoculture drug response assay (HDRA) for treatment of squamous cell carcinoma in the oral cavity. Nineteen patients with squamous cell carcinoma of the oral cavity were assessed. Tumor tissue samples were histocultured on Gelfoam sponge gels in ...

journal_title：Oral oncology

authors： Ariyoshi Y,Shimahara M,Tanigawa N

更新日期：2003-10-01 00:00:00

abstract：:We evaluated magnetic resonance images (MRI) and the value of dynamic contrast enhanced MRI (DCE-MRI) of pleomorphic adenomas retrospectively. MRI was performed for 18 pleomorphic adenomas, including 11 cases with DCE-MRI. We obtained the following results on the MRI and DCE-MRI. (a). Pleomorphic adenomas showed a pre...

journal_title：Oral oncology

authors： Hisatomi M,Asaumi J,Yanagi Y,Konouchi H,Matsuzaki H,Honda Y,Kishi K

更新日期：2003-09-01 00:00:00

abstract：:To assess the prognostic value of apoptosis, proliferation and clinical factors in squamous cell carcinoma of the oropharynx after radical surgery and postoperative radiotherapy (RT). Between 1985 and 1995, a total of 82 patients with 84 tumors were entered onto the study. Forty-two primary tumors (50%) involved the t...

journal_title：Oral oncology

authors： Grabenbauer GG,Suckorada O,Niedobitek G,Rödel F,Iro H,Sauer R,Rödel C,Schultze-Mosgau S,Distel L

更新日期：2003-07-01 00:00:00

abstract：:The purpose of this study was to investigate the association of the expression of vascular endothelial growth factor-C (VEGF-C) with regional lymph node metastasis in oral squamous cell carcinoma (OSCC). The expression of VEGF-C in biopsy specimens obtained from 62 patients with OSCC was examined by immunohistochemist...

journal_title：Oral oncology

authors： Kishimoto K,Sasaki A,Yoshihama Y,Mese H,Tsukamoto G,Matsumura T

更新日期：2003-06-01 00:00:00

abstract：:Mel-CAM (CD146) is a cell-cell adhesion protein found in normal and tumoral tissues. The aim of this study was to analyse Mel-CAM expression in mucoepidermoid carcinoma (MEC), and assess its importance in prognosis and its utility in differentiating high-grade MEC from squamous cell carcinoma (SCC). Immunohistochemica...

journal_title：Oral oncology

authors： Pires FR,Shih IeM,da Cruz Perez DE,de Almeida OP,Kowalski LP

更新日期：2003-04-01 00:00:00

abstract：:In this study, we focused on p53 mutations in specific regions, including DNA-binding surface regions, to clarify the correlation between mutations within the specific regions of p53 and clinical outcomes of patients with oral cancers. We analyzed p53 mutations in 121 fresh primary oral squamous cell carcinomas (SCCs)...

journal_title：Oral oncology

authors： Yamazaki Y,Chiba I,Hirai A,Sugiura C,Notani K,Kashiwazaki H,Tei K,Totsuka Y,Fukuda H

更新日期：2003-02-01 00:00:00

abstract：:Expression profile of 588 known genes relating to tumour biology, was examined between oral squamous cell carcinomas (OSCCs) and matching normal oral mucosal tissues (NOMTs) obtained from Sudanese (n=11) and Norwegian (n=11) patients. cDNA probes were synthesised from total RNA and hybridised with the Atlas human canc...

journal_title：Oral oncology

authors： Ibrahim SO,Aarsaether N,Holsve MK,Kross KW,Heimdal JH,Aarstad JH,Liavaag PG,Elgindi OA,Johannessen AC,Lillehaug JR,Vasstrand EN

更新日期：2003-01-01 00:00:00

abstract：:The techniques of lymphatic mapping and sentinel node biopsy are finding increasing utility in the management of the loco-regional lymphatics in many areas of oncology. Our unit is currently investigating their feasibility in relation to the management of the clinically node negative neck in oral squamous cell carcino...

journal_title：Oral oncology

authors： Hyde NC,Prvulovich E,Keshtgar MR

更新日期：2002-12-01 00:00:00

abstract：UNLABELLED:DNA microarray technology has been used for genome-wide gene expression studies that incorporate molecular genetics and computer science skills on massive levels. The technology permits the simultaneous analysis of tens of thousands of genes for the purposes of gene discovery, disease diagnosis. improved dru...

journal_title：Oral oncology

authors： Kuo WP,Whipple ME,Sonis ST,Ohno-Machado L,Jenssen TK

更新日期：2002-10-01 00:00:00

abstract：:There is relatively little data on salivary gland hypofunction (SGH) in patients with advanced cancer. The aim of the current study was to investigate the epidemiology, aetiology, and clinical features of SGH in this group of patients. The protocol involved completion of standard proforma, completion of a Memorial Sym...

journal_title：Oral oncology

authors： Davies AN,Broadley K,Beighton D

更新日期：2002-10-01 00:00:00

abstract：:Retinoids are the natural and synthetic derivatives of vitamin A. Epidemiological studies indicate that a low intake of vitamin A is associated with an increased risk of squamous cancer. In vitro studies on cancer cells show that exposure to retinoids results in the inhibition of growth, by blocking the cell cycle or ...

journal_title：Oral oncology

authors： Klaassen I,Braakhuis BJ

更新日期：2002-09-01 00:00:00

abstract：:To identify subgroups of oral cavity and pharynx (OCP) cancers that may be etiologically distinct, we evaluated age-adjusted incidence rates by histologic type, anatomical site, race, and sex using cases diagnosed during 1975-1998 in nine US Surveillance, Epidemiology, and End Results (SEER) program registries. Male/f...

journal_title：Oral oncology

authors： Canto MT,Devesa SS

更新日期：2002-09-01 00:00:00

abstract：:In this double-blind, randomized trial, we compared the clinical efficacy of intralesional vinblastine (VNB) and 3% sodium tetradecyl sulfate (STS) in the treatment of oral Kaposi's sarcoma (OKS). Subjects with OKS were randomly assigned to receive a single intralesional injection of either VNB or STS, at a standard d...

journal_title：Oral oncology

authors： Ramírez-Amador V,Esquivel-Pedraza L,Lozada-Nur F,De la Rosa-García E,Volkow-Fernández P,Súchil-Bernal L,Mohar A

更新日期：2002-07-01 00:00:00

abstract：:Hyalinizing clear cell carcinoma (HCCC) is a recently described low-grade carcinoma of the salivary glands presenting two main histological features: clear neoplastic cells and prominent hyalinized stroma. Our aim was to characterize the composition of the hyalinized stroma in three cases of HCCC. An immuno-histochemi...

journal_title：Oral oncology

authors： Félix A,Rosa JC,Nunes JF,Fonseca I,Cidadão A,Soares J

更新日期：2002-06-01 00:00:00

abstract：:Disruption of the homeostatic balance between proliferation and apoptosis is widely believed to contribute to human oral carcinogenesis. Using the Syrian hamster oral cancer model, we examined normal, hyperplastic, dysplastic and malignant oral epithelium for the fraction of apoptotic, proliferating and p12(doc-1) exp...

journal_title：Oral oncology

authors： Kohno Y,Patel V,Kim Y,Tsuji T,Chin BR,Sun M,Bruce Donoff R,Kent R,Wong D,Todd R

更新日期：2002-04-01 00:00:00

abstract：:The aim of this study is to assess the impact of prognostic factors in patients with locoregionally advanced nasopharyngeal cancer (NPC), WHO type II-III, treated with two different radiation therapy (RT) schedules: standard radiation therapy (SRT), and accelerated hyperfractionated radiation therapy (HART), with or w...

journal_title：Oral oncology

authors： Franchin G,Vaccher E,Talamini R,Gobitti C,Minatel E,Politi D,Sartor G,Trovò MG,Barzan L

更新日期：2002-02-01 00:00:00

abstract：:Clear cell tumours, in the head and neck region, are usually derived from salivary or odontogenic tissues, or may be metastatic. A few clear cells may be present in odontogenic cysts, while, odontogenic neoplasms composed predominantly of clear cells are quite rare. They include calcifying epithelial odontogenic tumou...

journal_title：Oral oncology

authors： Iezzi G,Rubini C,Fioroni M,Piattelli A

更新日期：2002-02-01 00:00:00

abstract：:Carboplatin (CBDCA) alone or in combination with irradiation and other chemotherapeutic agents has been used for the treatment of oral squamous carcinoma. However, there are some limitations for such therapy because of inherent or acquired resistance to CBDCA. To gain some insights into the association of CBDCA resist...

journal_title：Oral oncology

authors： Noutomi T,Chiba H,Itoh M,Toyota H,Mizuguchi J

更新日期：2002-01-01 00:00:00

abstract：:Sebaceous adenoma is a tumour only rarely located in the oral cavity. Less than 10 cases have been reported. Sebaceous adenoma represents 0.5-0.7% of all monomorphic adenomas. Sebaceous adenoma is mainly constituted by two types of cells, undifferentiated peripheral basaloid cells and cells showing different degrees o...

journal_title：Oral oncology

authors： Iezzi G,Rubini C,Fioroni M,Piattelli A

更新日期：2002-01-01 00:00:00

abstract：:Periodontal infection may exacerbate during cancer therapy and may result in oral pain and infection, and systemic infection, which may cause morbidity and can lead to mortality in neutropenic cancer patients. Periodontal disease in head and neck cancer patients treated with radiation therapy may lead to acute and chr...

journal_title：Oral oncology

authors： Epstein JB,Stevenson-Moore P

更新日期：2001-12-01 00:00:00

abstract：:Because of increased survival rates in childhood cancer, special interest has been focused on the side-effects of the therapy and the quality of life in long-term survivors. Our aim was to investigate craniofacial growth in children who had received different kinds of antineoplastic therapies for solid tumors. A total...

journal_title：Oral oncology

authors： Karsila-Tenovuo S,Jahnukainen K,Peltomäki T,Minn H,Kulmala J,Salmi TT,Rönning O

更新日期：2001-10-01 00:00:00

abstract：:We have established four cell lines from a human malignant fibrous histiocytoma. Each cell line had human aneuploid karyotype and DNA aneuploidy. Cells in all lines expressed CD13, CD68 and vimentin but lacked CD11, CD14, CD15, CD16, CD45, HLA class II and other mesenchymal and epithelial markers such as desmin, alpha...

journal_title：Oral oncology

authors： Mori A,Tagawa T,Kamei T,Murata T,Inui M,Ohse S

更新日期：2001-09-01 00:00:00

abstract：:Keratins have been extensively studied in tissues and cultured keratinocytes but limited information is available on epithelia reconstructed in vitro. The aim of this study was to examine keratin expression in organotypic epithelia with normal (NOK), immortalized (SVpgC2a) and malignant (SqCC/Y1) human buccal cells. O...

journal_title：Oral oncology

authors： Hansson A,Bloor BK,Haig Y,Morgan PR,Ekstrand J,Grafström RC

更新日期：2001-07-01 00:00:00

abstract：:Tumor growth is an angiogenesis-dependent process and therapeutic strategies aimed at inhibiting angiogenesis are theoretically attractive. Angiostatin has been shown to potently inhibit endothelial proliferation in vitro and tumor growth in vivo. We now show that a shift in the balance of tumor angiogenesis by gene t...

journal_title：Oral oncology

authors： Matsumoto G,Ohmi Y,Shindo J

更新日期：2001-06-01 00:00:00

abstract：:In recent years, studies on the malignant potential of oral lichen planus (OLP) provided clinical evidence that patients affected by OLP have an increased risk to develop oral squamous cell carcinoma (OSCC); nevertheless, controversies still exist as to whether OLP has inherent predisposition to become malignant, or n...

journal_title：Oral oncology

authors： Mignogna MD,Lo Muzio L,Lo Russo L,Fedele S,Ruoppo E,Bucci E

更新日期：2001-04-01 00:00:00

abstract：:We present four new cases of verruciform xanthoma (VX) in the oral mucosa and review the literature. Clinical, histological, and immunohistochemical features of four new cases of VX were analysed together with cases found in a review of the literature. Expression of CD-68 was studied by immunohistochemistry. Only 162 ...

journal_title：Oral oncology

authors： Oliveira PT,Jaeger RG,Cabral LA,Carvalho YR,Costa AL,Jaeger MM

更新日期：2001-04-01 00:00:00

abstract：:The effect of meat and fat in laryngeal carcinogenesis was examined in a case-control study carried out in Uruguay in the time period 1998-1999. One-hundred and forty patients with squamous cell laryngeal carcinoma and 420 hospitalized patients, afflicted with conditions not related with tobacco smoking, alcohol drink...

journal_title：Oral oncology

authors： Oreggia F,De Stefani E,Boffetta P,Brennan P,Deneo-Pellegrini H,Ronco AL

更新日期：2001-02-01 00:00:00

abstract：:Oral and pharyngeal cancer (OC) mortality is very low in Greece, especially among men, compared to other European countries. We conducted a case-control study of OC in Athens, and obtained information on tobacco, alcohol use and other potential risk factors and confounding variables for 110 incident cases and 115 hosp...

journal_title：Oral oncology

authors： Zavras AI,Douglass CW,Joshipura K,Wu T,Laskaris G,Petridou E,Dokianakis G,Segas J,Lefantzis D,Nomikos P,Wang YF,Diehl SR

更新日期：2001-01-01 00:00:00

abstract：:The aim was to determine the immediate influence of a validated patient information leaflet (PIL) on oral cancer and knowledge in primary care attenders. Participants were patients (n=800) attending their primary health care provider from 14 general practices (eight dental and six medical) in the north west of England...

journal_title：Oral oncology

authors： Humphris GM,Ireland RS,Field EA

更新日期：2001-01-01 00:00:00

abstract：:The high frequency of second or third primary tumors was first explained by Slaughter et al. with the concept of field cancerisation. Another theory postulates micrometastatic lesions as a reason for this phenomenon. The micronuclei (MN)-assay was evaluated to provide evidence for the concept of field cancerisation an...

journal_title：Oral oncology

authors： Bloching M,Hofmann A,Lautenschläger C,Berghaus A,Grummt T

更新日期：2000-11-01 00:00:00

abstract：:The relationship between basic fibroblast growth factor (bFGF), receptors for bFGF and neoangiogenesis was investigated in 51 patients with squamous cell carcinoma of the tongue, 26 of whom had metastatic disease in cervical lymph nodes. Vessels were demonstrated by immunocytochemical labelling for CD34 and expressed ...

journal_title：Oral oncology

authors： Forootan SS,Ke Y,Jones AS,Helliwell TR

更新日期：2000-09-01 00:00:00

abstract：:Spindle-cell lipoma (SCL) is a distinct histological variant of lipoma. Clinically, it appears as a solitary, subcutaneous, circumscribed lesion. SCL accounts for about 1.5% of all adipocytic tumours. Only nine cases of intraoral SCL were found in the literature. Microscopically, mature adipocytes and spindle cells ar...

journal_title：Oral oncology

authors： Piattelli A,Rubini C,Fioroni M,Iezzi G

更新日期：2000-09-01 00:00:00

abstract：:The role of the major risk factors, tobacco smoking and alcohol consumption, on trends in intra-oral cancer mortality in England and Wales between 1911 and 1990 was investigated, using lung cancer and liver cirrhosis as surrogate markers for smoking and drinking. Standardised mortality data on lung cancer and liver ci...

journal_title：Oral oncology

authors： Hindle I,Downer MC,Moles DR,Speight PM

更新日期：2000-07-01 00:00:00

abstract：:A patient is described who initially presented with pemphigus vulgaris, limited to the oral cavity, and weight loss. Although the various laboratory studies pointed to the diagnosis of paraneoplastic pemphigus (PNP), the underlying neoplasm was not detected until 6 months later, when the patient developed shortness of...

journal_title：Oral oncology

authors： van der Waal RI,Pas HH,Nousari HC,Schulten EA,Jonkman MF,Nieboer C,Stoof TJ,Starink TM,Anhalt GJ

更新日期：2000-07-01 00:00:00

abstract：:The inactivation of tumor suppressor gene (TSG) is important during multistage carcinogenesis. The p53 TSG is frequently mutated in oral squamous cell carcinomas. These mutations can serve as very specific markers for the presence of tumor cells in a background of normal cells. In this study, 10 oral squamous cell car...

journal_title：Oral oncology

authors： Liao PH,Chang YC,Huang MF,Tai KW,Chou MY

更新日期：2000-05-01 00:00:00